Breast cancer blog from bcancer.com

Time [GMT +0] : 11 Sep , 02:57:03

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07 Sep 2005 12:05:37 pm

One hormone treatment after another

Now there is even better news and hope for patients who have hormone receptor positive breast cancer. As per new research findings published in the September 7 issue of the Journal of the National Cancer Institute various hormonal agents can be used in optimal sequence to reduce the recurrence of breast cancer.

Researchers from Massachussetts General Hospital in Boston have found that switching women off tamoxifen and onto the drug letrozole may help keep them cancer-free.

Tamoxifen for five years post-surgery is now standard treatment for women with estrogen-linked breast cancer. However, over a period of time, cancer cells can become resistant to - or even dependent on - tamoxifen. Letrozole belongs to the group of aromatase inhibitors and works differently, lowering estrogen levels by selectively inhibiting a key enzyme called aromatase.

Researchers have found that just 3.6 percent of women who started taking letrozole at the end of their tamoxifen treatment experienced cancer recurrence, compared to 6 percent in a control group who started taking a placebo after finishing up with tamoxifen.

However, the Boston team noted that letrozole also led to more side effects, including osteoporosis and hot flashes, probably linked to estrogen depletion.

Category : Breast cancer treatment | Posted By : Sherin |

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