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| 03 Sep 2005 03:48:19 pm |
 Aromatase Inhibitors may cause menopausal arthritis |
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Aromatase inhibitors like arimedex, femara and aromasin have been hailed as the latest breakthrough medications for the treatment of hormone receptor positive breast cancer. They are usually considered as very benign drugs with minimal side effects. The commonest side effect associated with these drugs is hot flashes. These drugs may also minimally increase the risk of blood clots and uterine cancer.
Now there is increasing evidence to suggest that, use of aromatase inhibitors may have significant side effects. Women treated with aromatase inhibitors may experience joint pain and musculoskeletal aching often severe enough, in some cases, to make them stop the treatment.
Two prominent researchers, David T. Felson, M.D., of Boston University Clinical Epidemiology Unit, and Steven R. Cummings, M.D., of California Pacific Medical Center Research Institute and University of California, San Francisco, have thoroughly examined the evidence linking aromatase inhibitors and, more broadly, estrogen deprivation joint pain. Their findings were published in the September 2005 issue of Arthritis & Rheumatism.
This view is shared by other oncologists and primary care physicians in the community and is widely overlooked.
Estrogen has well-established tissue-specific effects on inflammatory cytokines. Estrogen's role in joint inflammation could account for the increased sensitivity to pain that some women suffer with estrogen depletion. Citing studies of pharmacological suppression of estrogen and studies of natural menopause, the authors offer a look at compelling evidence associating estrogen deprivation with joint pain. |
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Category : Breast cancer treatment
| Posted By : Sherin |  Comments [38] |  Trackbacks [1] |
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