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| 30 Jan 2006 01:37:21 pm |
 COX-2 Inhibitors Decrease Risk Of Breast Cancer |
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Use of selective COX-2 inhibitors on a regular basis may decrease your risk of developing breast cancer as per new research findings. Researchers say that regular use of COX-2 inhibitors like celecoxib (Celebrex) and rofecoxib (Vioxx) may reduce the risk of development of breast cancer by a71 percent.
The COX-2 inhibitors are a group of drugs which has activity in blocking the enzyme COX-2, which is an enzyme involved in the inflammation pathway. Many common drugs like aspirin, and ibuprofen has the capacity to block COX-2. Selective COX-2 inhibitors are a newer group of drugs, which can selectively inhibit COX-2 enzyme, while sparing COX-1 enzyme, thereby reducing gastrointestinal toxicity. Examples of selective COX-2 enzymes include celecoxib (Celebrex) and rofecoxib (Vioxx).
This new research finding regarding risk reduction associated with the regular use of selective COX-2 inhibitors is published in the journal BMC Cancer. Researchers also found that non-selective COX-2 inhibitors, such as aspirin and ibuprofen, also reduced the risk of breast cancer.
This research comes from Ohio State University College of Medicine and Public Health, Columbus, Ohio. Researchers Randall Harris and colleagues, collected data on 323 breast cancer patients with invasive breast cancer shortly after their diagnosis. They matched the patients for age, race and county of residence with 649 control individuals with no personal history of cancer.
Harris et al.'s results show that selective COX-2 inhibitors, as a group, were associated with a significantly reduced risk of breast cancer when taken daily for at least two years: a daily dose of 200 mg celecoxib reduced the risk of breast cancer by 83% and a daily dose of 25 mg rofecoxib reduced the risk of breast cancer by 64%.
Readers should be aware that rofecoxib (Vioxx) has been recently withdrawn from the US market due to increase risk of cardiac diseases associated with this drug. |
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Category : General
| Posted By : Sherin |  Comments [24] |  Trackbacks [0] |
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